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Fatty acids affect ulcerative colitis risk

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People who eat lots of red meat, cook with certain types of oil, and use some kinds of polyunsaturated fatty acid (PUFA)-heavy margarines may be increasing their risk of a painful inflammatory bowel disease. These foods are high in linoleic acid and people who are the heaviest consumers of this omega-6 PUFA are more than twice as likely to develop ulcerative colitis as those who consume the least.Researchers have found that eating more eicosapentaenoic acid, an omega-3 fatty acid found in fish and fish oils, is associated with a lower risk of the disease. While people need a certain amount of linoleic acid to survive, excess amounts are taken up into the lining of the colon, and if they’re released, they can promote inflammation. Omega-3 fatty acid does the opposite. It basically dampens down inflammation.

To investigate the role of fatty acids and ulcerative colitis, a life-long disease characterised by inflammation of the lining of the large intestine, researchers looked at data from the European Prospective Investigation into Cancer and Nutrition (EPIC) trial, which included over half a million people from 10 European countries. Their analysis included 203,193 men and women 30 to 74 years old. During follow-up, which ranged from about 2 to 11 years, 126 people developed ulcerative colitis.

It was found that people in the top quartile of linoleic acid intake (they were consuming around 13 to 38 grams a day) were 2.5 times more likely to have developed the disease than people who consumed the least, about 2 to 8 grams daily.

There’s currently no proven dietary treatment for ulcerative colitis but the current findings raise the possibility that eating a diet low in linoleic acid could be helpful. While a Western-style, red-meat-heavy diet is high in this fatty acid and low in omega-3s, a more Mediterranean style eating pattern – with plenty of fruits and vegetables, fish, and nut oils – would be low in linoleic acid and high in omega-3. If omega-3s do help prevent ulcerative colitis, eating a couple of servings of fish a week would probably be protective, the researchers concluded.

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